| Registro completo |
| Provedor de dados: |
BJID
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| País: |
Brazil
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| Título: |
Assessment of antioxidants status and superoxide dismutase activity in HIV-infected children
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| Autores: |
Pugliese,Camila
Patin,Rose Vega
Palchetti,Cecilia Zanin
Claudio,Cristiane Chiantelli
Gouvêa,Aída de Fátima Thomé Barbosa
Succi,Regina Célia de Menezes
Amancio,Olga Maria Silverio
Cozzolino,Silvia Maria Franciscato
Oliveira,Fernanda Luisa Ceragioli
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| Data: |
2014-10-01
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| Ano: |
2014
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| Palavras-chave: |
Antioxidants
HIV and nutrition
Oxidative stress
Trace elements
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| Resumo: |
Objective:This study aims to assess the nutritional status of selenium, copper and zinc; and also the erythrocyte superoxide dismutase activity of HIV-infected children compared to a control group.Methods:A cross-sectional study was carried out with prepubertal HIV-infected children (n = 51) and their healthy siblings (n = 32). All biochemical measurements including plasma selenium, serum copper levels, serum and erythrocyte zinc levels and erythrocyte super-oxide dismutase activity were evaluated according to dietary, clinical and biochemical parameters.Results:Compared to the control group, the HIV-infected children had lower z-score values for height-for-age (p = 0.0006), higher prevalence of stunting (11.8%) (p = 0.047), lower selenium levels (p = 0.0006) and higher copper levels (p = 0.019). No difference was found concerning superoxide dismutase activity (p > 0.05). The HIV-infected group presented a higher proportion (45.1%) of children with zinc intakes below the estimated average requirement (p = 0.014); however, no association with zinc biochemical parameters was found.Conclusion:HIV-infected children have an inadequate selenium and copper nutritional status, which could influence the progression to AIDS. An adequate micronutrient status could improve the clinical conditions in these patients and minimize free radical production and cellular oxidative stress.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500481
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| Editor: |
Brazilian Society of Infectious Diseases
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| Relação: |
10.1016/j.bjid.2014.02.003
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Infectious Diseases v.18 n.5 2014
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| Direitos: |
info:eu-repo/semantics/openAccess
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